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Q&A on resistance to main drug used to treat malaria (artemisinin)

There is a good summary here: Q&A on artemisinin resistance 

Artemisinin-based combination therapies (ACTs) are the main drugs used to treat malaria. In the majority of the world they work. In some parts of Asia resistance to ACTs has been seen because some strains of malaria are resistant to artemisinin. This is not good. There are five different ACTs and if one does not treat a particular patient, the patient is still cured as part of a longer treatment regimen, provided they are treated with an ACT containing a partner drug that is effective in that geographical area. So far, resistance is confined to four South-East Asian countries: Cambodia, Myanmar, Thailand, and Vietnam, all in the Greater Mekong subregion.

Geographic containment efforts may slow the spread of artemisinin resistance. A solution to artemisinin resistance is likely to require new malaria drugs not based on artemisinin.

Scientists have developed a simple, rapid blood test to determine the malaria parasite's resistance to artemisinin. This can help identify patients who need a second ACT to help them recover from malaria.

One implication of the reduction in efficacy of drugs to treat malaria is the need to work harder and faster to bring malaria under control so fewer people are at risk. And that’s where bednets come in.